Leon Kompowsky

Himself

Female Golem

Himself

Sammy Hagar

Fat Tony, Fit Tony

Kara DioGuardi

Hugh Hefner

Anderson Cooper

Ellen DeGeneres

Milhouse Van Houten, Jimbo Jones, Rod Flanders, Janey Powell, Sarah Wiggum, Additional Voices, Janey, Others, Boy, Dolph...

Himself

Happy Little Elf, Rubber Baby Buggy Bumper Babysitting Service Receptionist

Louie

Professor John Frink, Sr.

Bret 'The Hitman' Hart

Ned Flanders, Principal Skinner, Lenny, Kent Brockman, Dr. Hibbert, Mr. Burns, Waylon Smithers, Otto, Montgomery Burns, Reverend Lovejoy...

Karl

Marge Simpson, Patty Bouvier, Selma Bouvier, Jacqueline Bouvier, Others, Jackie Bouvier, Actress as Marge, Angela Lansburry, Audience, Aunt Gladys...

Linda McCartney

Himself

The Great Raymondo

Santa's Little Helper, Snowball II, African Animals, Baboons, Badger, Barnyard Animals, Buffalo, Cougar, Dolphins, Executive Vice-President...

Himself, Penn Jilette

Herb Powell

Dr. Zander, Judd Apatow, Paul Rudd

Henry, Simon Cowell

Nigel Baker-Butcher, Prince Charles, Queen Elizabeth II

Candace, Hannah Horvath

Leonard Nimoy

Himself